ConditionsImmune System DisordersSystemic Lupus Erythematosus (Lupus)
Blue Book Listing 14.02

Systemic Lupus Erythematosus (Lupus)

Chronic autoimmune disease that can affect multiple organ systems.

What you have to prove

Meet listing via: (1) involvement of two or more organs/body systems with one at a moderate level of severity AND two constitutional symptoms (severe fatigue, fever, malaise, weight loss), OR (2) repeated manifestations with marked limitation in daily activities, social functioning, OR completing tasks.

Medical evidence SSA expects

Rheumatologist records, ANA, anti-dsDNA, complement levels, organ-specific testing (renal biopsy, echo, skin biopsy), and treatment history including biologics or immunosuppressants.

Common misconceptions

Lupus varies dramatically between patients. Mild cases controlled with hydroxychloroquine rarely qualify; cases with significant organ involvement (lupus nephritis, pericarditis) often do.

Didn't meet the listing? You can still qualify via a Medical-Vocational Allowance — SSA's determination that your residual functional capacity, combined with your age, education, and work history, leaves no jobs you can do. See our appeals guide for what to do after an initial denial.